Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI).

Who Took Part

The age groups tagged for this paper are older adults, both men and women.

Eligible participants were between ages 65 and 84 years with MCI enrolled from September 19, 2016, to April 7, 2020.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

This randomized clinical trial (the SYNERGIC Study) was a multisite, double-masked, fractional factorial trial that evaluated the effects of aerobic-resistance exercise, computerized cognitive training, and vitamin D on cognition.

Data were analyzed from February 2021 to December 2022.

What Was Measured

PubMed files the paper under topics including Cognitive Training, Cognitive Dysfunction, Cognition, Vitamins, Vitamin D and Dietary Supplements.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (JAMA network open), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.