Biodegradable magnesium screw, titanium screw and direct embedding fixation in pedicled vascularized iliac bone graft transfer for osteonecrosis of the femoral head: a randomized controlled study.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The use of degradable magnesium screws to fix the bone flap implanted in the treatment of femoral head necrosis has achieved preliminary good therapeutic results.

Who Took Part

The study group was 12 patients.

A total of thirty-six patients (37 hips) with ONFH were recruited from March 2020 to July 2022.

The study used a single-blind method, and patients who underwent PVIBGT were randomized into three groups: 12 patients (12 hips) were fixed with biodegradable magnesium screws (Group A), 12 patients (13 hips) were fixed with titanium screws (Group B), 12 patients (12 hips) were directly embedded (Group C).

How the Study Was Run

The design is described as randomized and single-blind.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the patients, was kept unaware of whether Vitamin D, K2, Magnesium and Zinc was given.

The operating time and the length of stay were recorded.

Harris scores, radiological examinations (X-ray, CT, DCE-MRI), blood and serum tests were conducted before and after surgery.

The gas yield and degradation rates of the magnesium screws were measured at the 3-months and 6-months post-operative follow-ups in Group A.

What Was Measured

The subject headings attached to it are Magnesium, Titanium, Femur Head, Osteonecrosis and Bone Screws.

The authors tagged it with the keywords Biodegradable magnesium internal fixation screw, Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), Hip preservation, Osteonecrosis of the femoral head (ONFH) and Pedicled vascularized iliac bone graft transfer (PVIBGT).

What This Means in Plain Language

The paper is a randomized and single-blind study of Vitamin D, K2, Magnesium and Zinc in 12 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 13 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Journal of orthopaedic surgery and research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.