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Effects of vitamin D on sex steroids, luteinizing hormone, and testosterone to luteinizing hormone ratio in 307 infertile men.
Plain-language guide to PMID 37555466 (2024): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 307 men.
Key Facts
- PMID
- 37555466
- Journal
- Andrology
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Holt R et al. (7 authors)
- DOI
- 10.1111/andr.13505
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The question is whether vitamin D supplementation has an impact on sex steroid production in infertile men with vitamin D insufficiency?
Who Took Part
The study group was 307 men.
PubMed tags the participants as men only.
Differences in sex steroids and reproductive hormones were predefined secondary outcomes, vitamin D status at baseline was a predefined subgroup and the primary outcome was differences in semen quality.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the men and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
A single-center, double-blinded, randomized clinical trial.
What Was Measured
PubMed files the paper under topics including Calcium, Cholecalciferol, Dietary Supplements, Gonadal Steroid Hormones, Infertility, Luteinizing Hormone and Semen Analysis.
The authors tagged it with the keywords LH, Leydig cells and male infertility, testosterone and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 307 men.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2024 (Andrology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.