Effects of intraoperative Magnesium sulfate infusion on emergency agitation during general anesthesia in patients undergoing radical mastectomy: a randomized controlled study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The sedation-agitation scale (SAS) and the visual analogue scale were used to assess agitation and pain, respectively.

Why It Was Studied

Emergency agitation is a common postoperative complication in patients under general anesthesia, which can lead to unpredictable damages such as shedding of drainage tube and bleeding from the wound.

The study was registered in Chictr.org with the identifier: ChiCTR2300070595 on 18/04/2023.

Who Took Part

The abstract describes 70 patients taking part.

PubMed tags the participants as women only.

A total of 70 patients were randomly assigned to two groups: the Magnesium group (M group) and the control group (C group).

How the Study Was Run

In design terms this was a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

What Was Measured

Topics PubMed links to this paper include Magnesium Sulfate, Magnesium, Breast Neoplasms, Mastectomy, Anesthesia, General, Postoperative Pain and Mastectomy, Radical.

The authors tagged it with the keywords Emergency agitation and Radical mastectomy.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 70 patients.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (BMC anesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.