The effect of preemptive magnesium sulfate on postoperative pain in patients undergoing mastectomy: a clinical trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The effects of preemptive magnesium sulfate (MgSO4) infusion on perioperative hemodynamics and postoperative analgesia in female patients who underwent mastectomy were evaluated.

Who Took Part

The abstract describes 34 individuals taking part.

The age groups tagged for this paper are teenagers and adults, women only.

American Society of Anesthesiologists (ASA) I-II female patients aged 18 years and over who underwent mastectomy were randomized into 2 groups, including 34 individuals each.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Perioperative oxygen saturation, mean arterial pressure (MAP), pulse (HR), sedation scores (ss) in the recovery unit, Verbal Numeric Rating Scale (VNRS), need for rescuer fentanyl, and analgesic needs in the surgical period were evaluated.

What Was Measured

Topics PubMed links to this paper include Mastectomy, Magnesium Sulfate, Breast Neoplasms, Postoperative Pain and Anesthesia, General.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 34 individuals.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (European review for medical and pharmacological sciences), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.