The relationship of circulating MOTS-c level with liver fibrosis and metabolic components in patients with metabolic dysfunction-associated fatty liver disease.

What Was Tested

Researchers studied MOTS-c in the context of fatty liver & elevated liver enzymes in this human research study publication.

Mitochondrial open reading frame of the 12s ribosomal RNA type-c (MOTS-c) is a novel identified mitochondrial signal transmission peptide that plays an important role in glucose, amino acid and lipid metabolism.

In this study, the researchers aimed to investigate the relationship of circulating MOTS-c level with noninvasive scores of fibrosis and the components of metabolic syndrome (MetS) in patients with metabolic dysfunction-associated fatty liver disease (MAFLD).

Non-alcoholic fatty liver disease fibrosis score (NFS) and fibrosis 4 (FIB-4) were used to determine the level of liver fibrosis.

Who Took Part

By PubMed's age tags, the people studied were adults, men only.

This was a single-center cross-sectional study, and the participants were divided into two groups based on their liver ultrasound results: the fatty liver group and the healthy control group.

How the Study Was Run

The MOTS-c level was measured by the ELISA method.

Statistical analyses were performed using Statistical Package for Social Science 15.0 package program.

What Was Measured

Topics PubMed links to this paper include Non-alcoholic Fatty Liver Disease, Cross-Sectional Studies, Liver Cirrhosis, Lipid Metabolism, Amino Acids and Metabolic Syndrome.

What This Means in Plain Language

This is a human research study of MOTS-c in people with fatty liver & elevated liver enzymes.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2023 (European review for medical and pharmacological sciences), a journal based in Italy.

More context: the MOTS-c compound page, Fatty liver & elevated liver enzymes research.