Can Patients with Wilson's Disease Develop Copper Deficiency?

What It Covers

The paper reports a study of Copper (Supplement), published as a systematic review.

Study the characteristics of CD in WD patients.

Why It Was Studied

Wilson's disease (WD) is a rare genetic condition characterized by a copper overload in organs secondary to mutation in ATP7B gene.

Lifelong decoppering treatments are the keystone of the treatment but must be regularly adapted to obtain a correct copper balance and could lead to copper deficiency (CD).

Who the Included Studies Covered

By PubMed's age tags, the people studied were young adults, adults, middle-aged adults and older adults, both men and women.

CD cases from their cohort of 338 WD patients have been investigated.

A systematic review of literature about cases of CD in WD patient was performed in PubMed database according to PRISMA guidelines.

How the Review Was Done

CD was defined by the association of serum copper, exchangeable copper and urinary copper excretion assays less than two standard deviations from the mean with cytopenia and/or neurological damage of spinal cord origin.

What Was Measured

Wilson's disease (WD) is a rare genetic condition characterized by a copper overload in organs secondary to mutation in ATP7B gene.

Topics PubMed links to this paper include Copper and Hepatolenticular Degeneration.

Author keywords: Wilson's disease, anemia, copper deficiency, myeloneuropathy and zinc salts.

What This Means in Plain Language

This is a systematic review of Copper (Supplement).

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Movement disorders clinical practice), a journal based in United States.

More context: the Copper (Supplement) compound page, all human trials.