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MOTS-c Serum Concentration Positively Correlates with Lower-Body Muscle Strength and Is Not Related to Maximal Oxygen Uptake-A Preliminary Study.
Plain-language guide to PMID 37834399 (2023): human research study of MOTS-c.
Key Facts
- PMID
- 37834399
- Journal
- International journal of molecular sciences
- Year
- 2023
- Study type
- Journal Article
- Authors
- Domin R et al. (8 authors)
- DOI
- 10.3390/ijms241914951
What This Study Did, in Plain Language
What Was Tested
This human research study looks at MOTS-c.
The researchers aim to mainly investigate the relationship between serum MOTS-c concentration and muscle strength parameters measured during the countermovement jump test with oxygen consumption (VO2) measured during the cardiopulmonary exercise test to exhaustion.
Why It Was Studied
The mitochondrial open reading frame of 12S rRNA-c (MOTS-c) is a mitochondrial-derived peptide that regulates the nuclear genome during stressful conditions such as hypoxia, which is typical of exercise and training.
Physically active healthy volunteers (17 male, three female, median age 30 years), not involved in any regular exercise program or participating in any sports competitions, performed five consecutive countermovement jump tests and cardiopulmonary exercise tests until maximal exhaustion and underwent a body composition assessment by means of bioelectrical impedance analysis, and had serum MOTS-c concentration measured at rest.
Who Took Part
By PubMed's age tags, the people studied were adults, both men and women.
What Was Measured
Physically active healthy volunteers (17 male, three female, median age 30 years), not involved in any regular exercise program or participating in any sports competitions, performed five consecutive countermovement jump tests and cardiopulmonary exercise tests until maximal exhaustion and underwent a body composition assessment by means of bioelectrical impedance analysis, and had serum MOTS-c concentration measured at rest.
PubMed files the paper under topics including Muscle Strength, Exercise, Sports, Exercise Test, Muscle, Skeletal, Muscular Diseases and Oxygen.
The authors tagged it with the keywords countermovement jump test, exercise physiology, mitochondria-derived peptide, muscle force and muscle power.
What This Means in Plain Language
This is a human research study of MOTS-c.
The publication is from 2023 (International journal of molecular sciences), a journal based in Switzerland.
More context: the MOTS-c compound page, all human trials.
Our Notes on the Compound
MOTS-c: A 16-amino-acid peptide encoded in mitochondrial DNA.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.