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Concentration effect of DMSO-dry bonding on the stability of etch-and-rinse bonds.

Plain-language guide to PMID 37838609 (2023): randomized controlled trial of DMSO (dimethyl sulfoxide, non-peptide solvent).

Key Facts

PMID
37838609
Journal
Dental materials : official publication of the Academy of Dental Materials
Year
2023
Study type
Randomized Controlled Trial
Authors
Ismail OA et al. (3 authors)
DOI
10.1016/j.dental.2023.09.013

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of DMSO (dimethyl sulfoxide, non-peptide solvent), published as a randomized controlled trial.

To examine whether lower dimethyl sulfoxide (DMSO) concentrations would affect long-term bond stability of simplified or multistep water-based adhesives to dry-etched dentin.

Who Took Part

Restored crown segments (n = 5/group) were stored in distilled water for 24 h and sectioned for microtensile bond strength testing.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got DMSO (dimethyl sulfoxide, non-peptide solvent) and who got the comparison, which limits bias.

Untreated samples served as control.

Samples were bonded with a two-step or a three-step etch-and-rinse adhesive.

Resin-dentin beams (0.8 mm2) were tested under tension until fracture (0.5 mm/min) after 24 h and one year of storage in artificial saliva at 37 °C.

Nanoleakage evaluation and hybrid layer characterization were performed by SEM.

Bond strength data was examined by three-way ANOVA followed by the Tukey test (α = 0.05).

What Was Measured

Topics PubMed links to this paper include Dental Bonding, Dental Cements, Dentin, Dentin-Bonding Agents, Dimethyl Sulfoxide, Materials Testing and Resin Cements.

The authors tagged it with the keywords DMSO, Dental adhesives, Dry bonding and Hybrid layer.

What This Means in Plain Language

The paper is a randomized study of DMSO (dimethyl sulfoxide, non-peptide solvent).

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Dental materials : official publication of the Academy of Dental Materials), a journal based in England.

More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.

Our Notes on the Compound

DMSO (dimethyl sulfoxide, non-peptide solvent): A solvent that carries substances through skin and into the blood, described as a free-radical scavenger; not a peptide.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.