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The effect of vitamin D and omega-3 fatty acid supplementation on pain prevalence and severity in older adults: a large-scale ancillary study of the VITamin D and OmegA-3 triaL (VITAL).
Plain-language guide to PMID 37878483 (2024): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 25,871 men.
Key Facts
- PMID
- 37878483
- Journal
- Pain
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Soens MA et al. (12 authors)
- DOI
- 10.1097/j.pain.0000000000003044
- Registered trial
- NCT01169259
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
However, large, randomized placebo-controlled trials evaluating the effects of supplementation with omega-3 fatty acids and vitamin D on the presence and severity of pain are lacking.
The researchers assessed pain among those reaching the end of the VITAL intervention phase using questions from the 2012 National Health Interview Survey.
Who Took Part
The abstract describes 25,871 men taking part.
PubMed indexes the participants as middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The men were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the men nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some men received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
What Was Measured
However, large, randomized placebo-controlled trials evaluating the effects of supplementation with omega-3 fatty acids and vitamin D on the presence and severity of pain are lacking.
The researchers assessed pain among those reaching the end of the VITAL intervention phase using questions from the 2012 National Health Interview Survey.
The subject headings attached to it are Vitamin D, Fatty Acids, Omega-3, Prevalence, Vitamins, Cholecalciferol, Dietary Supplements and Pain.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 25,871 men.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2024 (Pain), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.