← Human Trials & Peer-Reviewed Studies
The Effect of Vitamin B12 Supplementation on Leukocyte Telomere Length in Mildly Stunted Nepalese Children: A Secondary Outcome of a Randomized Controlled Trial.
Plain-language guide to PMID 37918674 (2024): double-blind randomized controlled trial of Cyanocobalamin (Vitamin B12) in 600 infants.
Key Facts
- PMID
- 37918674
- Journal
- The Journal of nutrition
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Ulak M et al. (13 authors)
- DOI
- 10.1016/j.tjnut.2023.10.015
- Registered trial
- NCT02272842
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.
The study aims to determine the effect of vitamin B12 supplementation on leukocyte telomere length (LTL) in infants at risk of vitamin B12 deficiency.
Why It Was Studied
Vitamin B12 is essential for deoxyribonucleic acid synthesis and genome stability.
Who Took Part
The study group was 600 infants.
By PubMed's age tags, the people studied were infants, both men and women.
At the end of the study, LTL was measured in 497 participants.
Mean LTL was compared between the treatment arms in the full sample and predefined subgroups based on markers of vitamin B12 status, hemoglobin, sex, and growth indices.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The infants were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.
Neither the infants nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.
Some infants received a placebo instead of Cyanocobalamin (Vitamin B12), giving a reference point.
What Was Measured
The subject headings attached to it are Dietary Supplements, Growth Disorders, Leukocytes, Nepal, Telomere, Vitamin B 12 and Vitamin B 12 Deficiency.
Author keywords: children, leukocyte telomere length and vitamin B(12) supplementation.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 600 infants.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2024 (The Journal of nutrition), a journal based in United States.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.