Serum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet.

What Was Tested

The paper reports a study of Cyanocobalamin (Vitamin B12), published as a randomized controlled trial.

Vitamin B12 plays a crucial role in cognition, but its effect might be regulated by the presence of other micronutrients, such as folate.

Why It Was Studied

The study was conducted according to the guidelines of the Declaration of Helsinki and was approved by the Institutional Review Board of the 11 participating centres.

The study was registered with the International Standard Randomized Controlled Trial Number (ISRCTN) 35739639 (https://www.isrctn.com/ISRCTN35739639).

Who Took Part

The abstract describes 170 participants taking part.

The age groups tagged for this paper are older adults.

A total of 170 participants of the PREDIMED trial (Barcelona - Hospital Clinic site) aged 55-80 years at high cardiovascular risk were included.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.

This is a cohort study nested in a randomized controlled clinical trial performed in Hospital Clinic in Barcelona, Spain.

Adherence to the Mediterranean diet was assessed using a validated 14-item questionnaire, memory function was evaluated with a battery of neuropsychological tests and serum vitamin B12 and folate were determined using an automated electrochemiluminiscence immunoassay system.

What Was Measured

The subject headings attached to it are Diet, Mediterranean, Cohort Studies, Folic Acid, Vitamin B 12 and Vitamins.

Author keywords: Bioactive compounds, Cognition, Mediterranean diet and PREDIMED.

What This Means in Plain Language

The paper is a randomized study of Cyanocobalamin (Vitamin B12) in 170 participants.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2023 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.