← Human Trials & Peer-Reviewed Studies
Vitamin D supplements for fracture prevention in schoolchildren in Mongolia: analysis of secondary outcomes from a multicentre, double-blind, randomised, placebo-controlled trial.
Plain-language guide to PMID 38048799 (2024): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 38048799
- Journal
- The lancet. Diabetes & endocrinology
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Ganmaa D et al. (14 authors)
- DOI
- 10.1016/S2213-8587(23)00317-0
- Registered trial
- NCT02276755
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
US National Institutes of Health.
Who Took Part
The age groups tagged for this paper are children and teenagers, both men and women.
Participants, care providers, and all trial staff were masked to group assignment during the intervention.
The fracture and safety analyses included participants who completed at least one follow-up fracture questionnaire.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and multicenter.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
More than one site took part, so the participants came from several places.
The researchers did a multicentre, double-blind, randomised, placebo-controlled trial across 18 public schools in Ulaanbaatar, Mongolia.
Prespecified secondary outcomes were incidence of fractures and adverse events, ascertained using questionnaires.
The trial is registered with ClinicalTrials.gov, NCT02276755, and the intervention ended in May, 2019.
What Was Measured
PubMed files the paper under topics including Mongolia, Vitamin D, Vitamins, Cholecalciferol, Fractures, Bone and Dietary Supplements.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2024 (The lancet. Diabetes & endocrinology), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.