Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: Prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial.

Plain-language guide to PMID 38051700 (2023): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 38051700
Journal: PLoS medicine
Year: 2023
Study type: Randomized Controlled Trial
Authors: Godfrey KM et al. (12 authors)
DOI: 10.1371/journal.pmed.1004260
Registered trial: NCT02509988

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Maternal vitamin status preconception and during pregnancy has important consequences for pregnancy outcome and offspring development.

Changes in vitamin status from preconception through early and late pregnancy and postpartum have been inferred from cross-sectional data, but longitudinal data on vitamin status from preconception throughout pregnancy and postdelivery are sparse.

Who Took Part

The age groups tagged for this paper are teenagers, young adults and adults, women only.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

What Was Measured

Maternal vitamin status preconception and during pregnancy has important consequences for pregnancy outcome and offspring development.

This study presents one prespecified outcome from the randomized controlled NiPPeR trial, aiming to identify longitudinal patterns of maternal vitamin status from preconception, through early and late pregnancy, to 6 months postdelivery, and determine the influence of vitamin supplementation.

PubMed files the paper under topics including Cross-Sectional Studies, Dietary Supplements, Folic Acid, Pregnancy Outcome, Riboflavin, Vitamin B 12 and Vitamin B 6.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 16 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2023 (PLoS medicine), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.