Bone mineral density, vitamin D and osseous metabolism indices in neurofibromatosis type 1: A systematic review and meta-analysis.

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in this meta-analysis publication.

A meta-analysis was performed to investigate the effects of NF1 on bone mineral density (BMD) and osseous metabolic indices in order to provide clinical evidence for the pathogenesis of the associated skeletal deformities.

The Newcastle-Ottawa and Jadad scales were applied to assess the quality of the included studies.

RevMan 5.3 software was used for the analysis of the data, and MedCalc was applied to examine publication bias.

Why It Was Studied

Neurofibromatosis type 1 (NF1) is a genetic autosomal neurocutaneous syndrome correlated with skeletal dysplasia and defects in the osseous microarchitecture.

The physiological mechanism for the development of NF1-related bone abnormal turnover is still unclear.

Who the Included Studies Covered

PubMed indexes the participants as children and adults.

Specific inclusion and exclusion criteria were applied for the identification of studies examining the effects of NF1 on bone strength and metabolism.

How the Review Was Done

A systematic literature review search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in the PubMed/Medline and Web of Science databases from the date of inception of each database through to 10 September 2023.

What Was Measured

Topics PubMed links to this paper include Bone Density, Vitamin D, Neurofibromatosis 1, Calcium, Cross-Sectional Studies, Osteocalcin and Parathyroid Hormone.

Author keywords: Biochemical indexes, Bone mineral density, Neurofibromatosis-1 and Osseous metabolism markers.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Bone), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.