Effect of daily zinc supplementation for 12 weeks on serum thyroid auto-antibody levels in children and adolescents with autoimmune thyroiditis - a randomized controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Who Took Part

The age groups tagged for this paper are children and teenagers, both men and women.

How the Study Was Run

In design terms this was a randomized, open-label and parallel-group study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Everyone knew when Vitamin D, K2, Magnesium and Zinc was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

This open-labeled, parallel, randomized controlled trial was done in a tertiary care teaching institute in south India.

The change in thyroid function tests (thyroid stimulating hormone, free T3, free T4), thyroid auto-antibody (TPOAb, TgAb) titers, oxidative stress markers (glutathione peroxidase, malondialdehyde, superoxide dismutase, and total antioxidant capacity) were compared.

What Was Measured

The subject headings attached to it are Thyroxine, Zinc, Thyroiditis, Autoimmune, Hashimoto Disease, Autoantibodies, Iodide Peroxidase and Dietary Supplements.

The authors tagged it with the keywords children and oxidative stress.

What This Means in Plain Language

The paper is a randomized, open-label and parallel-group study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2024 (Journal of pediatric endocrinology & metabolism : JPEM), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.