Can instrumentation kinematics affect postoperative pain and substance P levels? A randomized controlled trial

What Was Tested

Researchers studied Substance P in this randomized controlled trial publication.

This study aimed to assess the influence of continuous rotation and reciprocation kinematics on postoperative pain (POP) levels and substance P (SP) levels in patients diagnosed with irreversible pulpitis and symptomatic apical periodontitis (SAP).

Why It Was Studied

The study protocol was retrospectively registered on the www.

Gov database (NCT06081335) at (13/10/2023) after the approval of the Ethics Committee, Faculty of Dentistry, Ain Shams University (FDASU-RecIM012135).

Who Took Part

A total of twenty patients were randomly assigned into two groups: Continuous Rotation Group (CRG) (n = 10), subjected to mechanical preparation with the EdgeEndox7 rotary system (Albuquerque, NM, USA), and Reciprocation Group (RG) (n = 10), treated with the EdgeOne Fire reciprocating system (Albuquerque, NM, USA).

Data were statistically analyzed utilizing the independent t-test, Mann-Whitney U test, Friedman's test, and Nemenyi post hoc test.

How the Study Was Run

The design is described as randomized.

The participants were allocated by chance, so the Substance P group and the comparison group should start out alike.

Apical fluid (AF) samples were collected, and SP levels were quantified through radioimmunoassay.

POP was assessed using the Numerical Rating Scale (NRS) at various time intervals (preoperatively, 6 h, 12 h, 24 h, 48 h, and 72 h).

What Was Measured

Topics PubMed links to this paper include Substance P, Biomechanical Phenomena, Root Canal Preparation, Pulpitis and Postoperative Pain.

Author keywords: Continuous rotation, Reciprocation and Symptomatic apical periodontitis.

What This Means in Plain Language

The paper is a randomized study of Substance P.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (BMC oral health), a journal based in England.

More context: the Substance P compound page, all human trials.