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Effect of calcium and Vitamin D supplementation on residual ridge resorption in edentulous patients: An open-label randomized study.

Plain-language guide to PMID 38263558 (2024): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
38263558
Journal
Journal of Indian Prosthodontic Society
Year
2024
Study type
Randomized Controlled Trial
Authors
Singh SV et al. (6 authors)
DOI
10.4103/jips.jips_455_23

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Complete dentures (CDs) are fabricated to rehabilitate the edentulous.

Severe residual ridge resorption (RRR) compromises CD functionality, adversely affecting function, appearance, systemic health, and quality of life.

Who Took Part

This longitudinal, parallel, open-label randomized study was conducted in the Department of Prosthodontics of the institute.

One hundred and fifty edentulous subjects underwent bone mineral density (BMD) assessment followed by CD fabrication to measure RR height and width with computerized tomographic (CT) scans.

How the Study Was Run

The design is described as randomized, open-label and parallel-group.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Being open-label, the Vitamin D, K2, Magnesium and Zinc study did not mask who received what.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

Mean BMD, RR height and width, and RRR values were collected, analyzed, and compared for the two groups using STATA 17.

What Was Measured

PubMed files the paper under topics including Quality of Life, Calcium, Dietary, Mouth, Edentulous, Vitamin D and Dietary Supplements.

What This Means in Plain Language

The paper is a randomized, open-label and parallel-group study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2024 (Journal of Indian Prosthodontic Society), a journal based in India.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.