High brain natriuretic peptide level is associated with severe stroke in patients taking oral anticoagulants: A sub-analysis of the PASTA registry study

What Was Tested

This observational study looks at BNP (Nesiritide).

In this study, the researchers aimed to investigate the association between stroke severity at admission and BNP levels.

Why It Was Studied

Brain natriuretic peptides (BNP) are an important diagnostic and prognostic marker in patients with heart failure.

However, the relationship between BNP levels and stroke severity in patients with atrial fibrillation (AF) remains unelucidated.

Who Took Part

The study group was 513 patients.

PubMed indexes the participants as older adults and people over 80, women only.

In this prospective observational study, the researchers used data from 513 patients with AF and acute ischemic stroke treated with oral anticoagulants (OAC) registered in the Multicenter Prospective Analysis of Stroke Patients Taking Oral Anticoagulants study.

The patients were divided into two groups: high-BNP (≥200 pg/mL) and low-BNP level (<200 pg/mL) groups.

How the Study Was Run

In design terms this was a multicenter study.

More than one site took part, so the patients came from several places.

The researchers compared the clinical characteristics between the two groups and determined the effect of BNP levels on stroke severity on admission.

What Was Measured

However, the relationship between BNP levels and stroke severity in patients with atrial fibrillation (AF) remains unelucidated.

PubMed files the paper under topics including Natriuretic Peptide, Brain, Ischemic Stroke, Biomarkers, Stroke and Atrial Fibrillation.

Author keywords: Anticoagulants, Brain natriuretic peptide, Heart failure, Large vessel occlusion and Stroke severity.

What This Means in Plain Language

The paper is a multicenter study of BNP (Nesiritide) in 513 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Journal of the neurological sciences), a journal based in Netherlands.

More context: the BNP (Nesiritide) compound page, all human trials.