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Characterisation of biomarkers of intestinal barrier function in response to a high fat/high carbohydrate meal and corticotropin releasing hormone
Plain-language guide to PMID 38408050 (2024): single-blind randomized controlled trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 38408050
- Journal
- PloS one
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Mogilevski T et al. (7 authors)
- DOI
- 10.1371/journal.pone.0294918
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Variation of circulating concentrations of putative biomarkers of intestinal barrier function over the day and after acute physiological interventions are poorly documented on humans.
Who Took Part
PubMed tags the participants as both men and women.
Participants were allowed low caloric food.
How the Study Was Run
The design is described as randomized, single-blind, placebo-controlled and crossover.
Random assignment meant chance, not the researchers, decided who got ACTH (Corticotropin) and who got the comparison, which limits bias.
Only one side, usually the participants, was kept unaware of whether ACTH (Corticotropin) was given.
A placebo (an inactive look-alike) gave the ACTH (Corticotropin) group a baseline to be compared against.
In the crossover set-up each of the participants took both ACTH (Corticotropin) and the comparison in turn, acting as their own control.
Markers of intestinal barrier function were measured at set timed intervals from 30 minutes before to 24 hours after interventions.
What Was Measured
Variation of circulating concentrations of putative biomarkers of intestinal barrier function over the day and after acute physiological interventions are poorly documented on humans.
The subject headings attached to it are Corticotropin-Releasing Hormone, Syndecan-1, Intestinal Barrier Function, Lipopolysaccharides and Biomarkers.
What This Means in Plain Language
The paper is a randomized, single-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2024 (PloS one), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.