The Effects of Vitamin D Supplementation on C-Reactive Protein and Systolic and Diastolic Blood Pressure in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension.

This systematic review of RCTs was conducted to assess the effect of vitamin D supplementation on CRP, systolic blood pressure (SBP), and diastolic blood pressure (DBP) in postmenopausal women.

Why It Was Studied

An inverse relationship between vitamin D supplementation and C-reactive protein (CRP) and hypertension has been reported, mostly through observational data.

This inverse relationship, however, has not been confirmed in randomized controlled trials (RCTs).

Who the Included Studies Covered

PubMed tags the participants as women only.

Changes from baseline and SDs of CRP, SBP, and DBP were compared between postmenopausal women who received vitamin D supplementation and those who did not (controls).

How the Review Was Done

Four databases (PubMed, Web of Science, Embase, and Scopus) were systemically searched to identify relevant RCTs published in international scientific journals up to January 2023.

These parameters were applied to compute the overall effect sizes using the random-effects model.

Heterogeneity among arms was scrutinized using the Cochrane's Q test and I2 statistic.

Publication bias was judged by means of funnel plots and Egger's test.

What Was Measured

The subject headings attached to it are Blood Pressure, C-Reactive Protein, Postmenopause, Randomized Controlled Trials as Topic, Dietary Supplements and Vitamin D.

The authors tagged it with the keywords CRP, Inflammation, Meta-analysis and Postmenopausal women.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Journal of the Academy of Nutrition and Dietetics), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.