The effect of three years of vitamin D supplementation on erectile dysfunction: Results from the randomized placebo-controlled D-Health Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

However, this association may be due to uncontrolled confounding, and there is a paucity of evidence from interventional studies.

The researchers aimed to examine the effect of vitamin D supplementation on the prevalence of erectile dysfunction, in an exploratory analysis using data from a large randomized controlled trial.

The researchers used log-binomial regression to examine the effect of vitamin D on the prevalence of erectile dysfunction overall, and within sub-groups.

Who Took Part

By PubMed's age tags, the people studied were middle-aged adults, older adults and people over 80, men only.

Blood samples were collected annually from randomly selected participants (total N = 3943).

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

The researchers assessed erectile dysfunction at the end of the third year of follow-up.

What Was Measured

Topics PubMed links to this paper include Australasian People, Australia, Calcifediol, Dietary Supplements, Erectile Dysfunction, Vitamin D and Vitamins.

The authors tagged it with the keywords Impotence.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2024 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.