Effect of Intraoperative infusion Magnesium Sulfate Infusion on Postoperative Quality of Recovery in Patients Undergoing Total Knee Arthroplasty: A Prospective, Double-Blind, Randomized Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Therefore, the present experiment aimed to investigate the effect of continuous intravenous magnesium sulfate on the quality of postoperative recovery in elderly patients undergoing total knee arthroplasty (TKA).

Why It Was Studied

Magnesium sulfate, an intravenous adjuvant, has recently attracted immense attention in multimodal analgesia.

Previous studies confirmed the crucial role of magnesium sulfate in postoperative pain and nociceptive hypersensitivity.

Who Took Part

The study group was 148 patients.

PubMed indexes the participants as older adults.

In this study, a total of 148 patients scheduled to undergo unilateral total knee arthroplasty were randomized into a magnesium sulfate group (Group M, n=68) and a control group (Group C, n=66) using a double-blind, randomized controlled trial.

How the Study Was Run

The design is described as randomized and double-blind.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Blinding on both sides kept the patients and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

In the same manner, Group C received an infusion of the same amount of isotonic saline using the same method as the Group M.

What Was Measured

PubMed files the paper under topics including Magnesium Sulfate, Arthroplasty, Replacement, Knee, Analgesics, Postoperative Pain and Analgesics, Opioid.

The authors tagged it with the keywords multimodal analgesic regimen, quality of recovery and total knee arthroplasty.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 148 patients.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Drug design, development and therapy), a journal based in New Zealand.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.