A randomized clinical trial investigating the impact of magnesium supplementation on clinical and biochemical measures in COVID-19 patients.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study sought to examine the impact of magnesium supplementation on clinical outcomes and biochemical factors among hospitalized patients with COVID-19.

Why It Was Studied

This study is registered on Iranian Registry of Clinical Trials (IRCT) under identifier IRCT20210413050957N1.

(The registration date: May 1, 2021).

Who Took Part

PubMed indexes the participants as teenagers, young adults, adults, middle-aged adults and older adults, both men and women.

Participants aged 18-70 years with moderate disease severity were enrolled.

Clinical outcomes, including the need for oxygen therapy, oxygen saturation, respiratory rate, fever, hs-CRP and TNF-α levels, as well as quality of life and mental health, were assessed.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

This double-blind, randomized clinical trial was conducted at Razi Hospital, Ahvaz, Iran, between September 2021 and March 2022.

Blood samples were collected to measure biochemical variables.

What Was Measured

Topics PubMed links to this paper include Magnesium, Dietary Supplements, COVID-19, Iran, Quality of Life, SARS-CoV-2 and COVID-19 Drug Treatment.

Author keywords: Clinical trials and Disease management.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Virology journal), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.