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Influence of folic acid and vitamin B12 supplementation on arsenic methylation: A double-blinded, placebo-controlled trial in Bangladeshi children.
Plain-language guide to PMID 38728816 (2024): double-blind randomized controlled trial of Cyanocobalamin (Vitamin B12) in 240 participants.
Key Facts
- PMID
- 38728816
- Journal
- Environment international
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Martinez-Morata I et al. (18 authors)
- DOI
- 10.1016/j.envint.2024.108715
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Cyanocobalamin (Vitamin B12).
Generalized estimated equation (GEE) models were used to assess treatment effects on arsenic species in blood and urine.
Why It Was Studied
Inorganic arsenic is metabolized to monomethyl- (MMAs) and dimethyl- (DMAs) species via one-carbon metabolism (OCM); this facilitates urinary arsenic elimination.
This RCT investigated the effects of FA + B12 supplementation on arsenic methylation in children, a key developmental stage where OCM supports growth.
Who Took Part
The study group was 240 participants.
PubMed indexes the participants as children, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Cyanocobalamin (Vitamin B12) could be set against what happens without it.
Urine and blood samples were collected at baseline, week 1 (only urine) and week 12.
What Was Measured
The subject headings attached to it are Folic Acid, Arsenic, Vitamin B 12, Dietary Supplements, Bangladesh and Methylation.
The authors tagged it with the keywords Arsenic Methylation, Biomarkers, Children, DMAs, MMAs and Nutrition.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Cyanocobalamin (Vitamin B12) in 240 participants.
The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2024 (Environment international), a journal based in Netherlands.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.