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Blood pressure monitoring in elderly migraineurs starting an anti-CGRP monoclonal antibody: a real-world prospective study
Plain-language guide to PMID 38795273 (2024): multicenter observational study of CGRP (Calcitonin Gene-Related Peptide), low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 38795273
- Journal
- Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
- Year
- 2024
- Study type
- Observational Study
- Authors
- Mascarella D et al. (10 authors)
- DOI
- 10.1007/s10072-024-07567-9
What This Study Did, in Plain Language
What Was Tested
Researchers studied CGRP (Calcitonin Gene-Related Peptide) in the context of low blood pressure and orthostatic hypotension and migraine in this observational study publication.
Given the growing use of these therapies in older populations, assessing their cardiovascular (CV) safety is of paramount importance.
Who Took Part
By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.
Baseline, three-month, and twelve-month BP measurements were collected.
Changes in antihypertensive medication and "Newly or Worsened Hypertensive" patients (NWHP) were assessed.
How the Study Was Run
The researchers set it up as a multicenter study.
Running at several centres spread the CGRP (Calcitonin Gene-Related Peptide) study over different clinics and patient groups.
What Was Measured
Given the growing use of these therapies in older populations, assessing their cardiovascular (CV) safety is of paramount importance.
PubMed files the paper under topics including Migraine Disorders, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, Blood Pressure, Hypertension, Calcitonin Gene-Related Peptide and Calcitonin Gene-Related Peptide Receptor Antagonists.
Author keywords: Anti-CGRP, CGRP, Cardiovascular safety, Elderly, Erenumab and Fremanezumab.
What This Means in Plain Language
The paper is a multicenter study of CGRP (Calcitonin Gene-Related Peptide) in people with low blood pressure and orthostatic hypotension.
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2024 (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology), a journal based in Italy.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Low blood pressure and orthostatic hypotension research, Migraine research.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Migraine research
- CGRP (Calcitonin Gene-Related Peptide) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.