Prenatal Magnesium Sulfate and Functional Connectivity in Offspring at Term-Equivalent Age.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Who Took Part

The abstract describes 159 infants taking part.

The age groups tagged for this paper are infants and adults, both men and women.

Participants included infants born to women at risk of imminent preterm birth at a gestational age between 30 and 34 weeks who participated in the MAGENTA (Magnesium Sulphate at 30 to 34 Weeks' Gestational Age) trial and underwent magnetic resonance imaging (MRI) at term-equivalent age.

Ineligibility criteria included illness precluding MRI, congenital or genetic disorders likely to affect brain structure, and living more than 1 hour from the MRI center.

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some infants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

This cohort study was nested within a randomized placebo-controlled trial performed across 24 tertiary maternity hospitals.

One hundred and fourteen of 159 eligible infants were excluded due to incomplete or motion-corrupted MRI.

Recruitment occurred between October 22, 2014, and October 25, 2017.

Analysis was performed from February 1, 2021, to February 27, 2024.

Observers were blind to patient groupings during data collection and processing.

What Was Measured

PubMed files the paper under topics including Magnesium Sulfate, Magnetic Resonance Imaging, Gestational Age, Cohort Studies, Premature Birth, Brain and Prenatal Care.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 159 infants.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2024 (JAMA network open), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.