Magnesium and Esophageal Pain After Peroral Endoscopic Myotomy of the Esophagus: A Randomized, Double-Blind, Placebo-Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Magnesium can act as a smooth muscle relaxant.

Who Took Part

The abstract describes 92 patients taking part.

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

Intraoperative analgesia was standardized in all patients.

Pain scores, opioid requirements, and questionnaire scores were collected through postoperative day 1.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The primary outcome was the score from a validated, modified Esophageal Symptoms Questionnaire (ESQ) in the postanesthesia care unit (PACU).

What Was Measured

Topics PubMed links to this paper include Postoperative Pain, Magnesium Sulfate, Pain Measurement, Analgesics, Opioid, Esophagus and Esophagoscopy.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 92 patients.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Anesthesia and analgesia), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.