Attenuation of acute postoperative pain and opioid requirement with the use of magnesium sulfate in patients undergoing limb amputations.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Who Took Part

The age groups tagged for this paper are young adults, adults and middle-aged adults, both men and women.

This prospective, triple-blinded, randomised controlled study was conducted from October 2021 to May 2022 at the Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan, and comprised of patients scheduled for limb amputations.

The anaesthesia protocol was uniform for all patients.

How the Study Was Run

The design is described as randomized.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

They were randomised into 2 equal groups.

Numeric rating scale was used for the evaluation of postoperative pain in both groups at 15min, 1h, 2h, at discharge from the post-anaesthesia care unit and at 12h and 24h in the ward.

Data was analysed using SPSS 23.

What Was Measured

The subject headings attached to it are Postoperative Pain, Magnesium Sulfate, Analgesics, Opioid, Morphine, Amputation, Surgical, Pain Measurement and Analgesia, Patient-Controlled.

Author keywords: Postoperative pain, Analgesia, Amputation, Surgical amputation, N-methyl-D-aspartate receptors, Magnesium, Magnesium sulphate, Opioid analgesics, Morphine, Patient-controlled analgesia.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (JPMA. The Journal of the Pakistan Medical Association), a journal based in Pakistan.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.