Association of serum homocysteine with vitamin B12 and folate levels in women with pre-eclampsia in a tertiary health care center in Nepal.

What Was Tested

The paper reports a study of Cyanocobalamin (Vitamin B12), published as an observational study.

This study was designed to evaluate the association of homocysteine with Vitamin B12 and folate in patients with pre-eclampsia.

Why It Was Studied

Pre-eclampsia is one of the major causes of mortality and morbidity in Nepal.

Hyperhomocysteinemia may be a cause of the endothelial dysfunction provoked by oxidative stress in pre-eclampsia.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, women only.

An observational cross sectional study was performed in the Gynecology and Obstetrics Department of TUTH involving seventy two subjects with pre-eclampsia.

How the Study Was Run

Blood pressure, urinary protein levels, serum homocysteine, Vitamin B12 and folate levels were compared in both mild and severe forms of pre-eclampsia.

Concentration of Vitamin B12 and folate were measured using Vitros ECI and homocysteine was measured using CLIA.

SPSS 23.0 was used to analyze the data.

Tests were performed with Mann Whitney Test and Spearman's rank correlation test.

What Was Measured

Topics PubMed links to this paper include Pre-Eclampsia, Homocysteine, Folic Acid, Vitamin B 12, Nepal, Cross-Sectional Studies and Tertiary Care Centers.

The authors tagged it with the keywords Hypertension and Pregnancy.

What This Means in Plain Language

This is an observational study of Cyanocobalamin (Vitamin B12).

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2024 (BMC women's health), a journal based in England.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.