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The Effect of 4-Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx Integrity and Vascular Function in Patients with Psoriasis.
Plain-language guide to PMID 39125451 (2024): double-blind randomized controlled trial of Copper (Supplement), psoriasis and psoriatic arthritis.
Key Facts
- PMID
- 39125451
- Journal
- Nutrients
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Ikonomidis I et al. (17 authors)
- DOI
- 10.3390/nu16152572
- Registered trial
- NCT05184699
What This Study Did, in Plain Language
What Was Tested
Researchers studied Copper (Supplement) in the context of psoriasis and psoriatic arthritis in this randomized controlled trial publication.
Psoriasis predisposes to cardiovascular dysfunction.
The researchers measured at baseline and at follow-up: (a) perfused boundary region (PBR) of the sublingual microvessels (range 4 to 25 μm), a marker of endothelium glycocalyx integrity; (b) carotid-femoral pulse wave velocity (PWV-Complior SP-ALAM) and augmentation index (AIx), markers of arterial stiffness and (c) psoriasis area and severity index (PASI) score.
Who Took Part
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.
As a double-blind Copper (Supplement) study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.
What Was Measured
The researchers measured at baseline and at follow-up: (a) perfused boundary region (PBR) of the sublingual microvessels (range 4 to 25 μm), a marker of endothelium glycocalyx integrity; (b) carotid-femoral pulse wave velocity (PWV-Complior SP-ALAM) and augmentation index (AIx), markers of arterial stiffness and (c) psoriasis area and severity index (PASI) score.
PubMed files the paper under topics including Glycocalyx, Psoriasis, Dietary Supplements, Vascular Stiffness and Endothelium, Vascular.
The authors tagged it with the keywords arterial stiffness, augmentation index, fucoidan, glycocalyx dietary supplement and pulse wave velocity.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement) in people with psoriasis and psoriatic arthritis.
The publication is from 2024 (Nutrients), a journal based in Switzerland.
More context: the Copper (Supplement) compound page, Psoriasis and psoriatic arthritis research.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.