Association of vitamin D status and vitamin D receptor polymorphism in diabetic foot ulcer patients: A prospective observational study in a South-Indian tertiary healthcare facility.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

Objective of the study was to find the association of vitamin D receptor (VDR) polymorphisms (Fokl, Taql and Apal) with vitamin D levels in diabetic foot ulcer (DFU) patients in South India.

Why It Was Studied

In this case-control study, plasma vitamin D levels and VDR genotype frequencies of 70 cases (DFU patients) were compared with 70 diabetic (diabetes mellitus [DM] [non-DFU]) patients and 70 apparently healthy controls (HC) from South India.

Logistic regression was used to find the association between DFU versus HC and DFU versus DM traits.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

Plasma vitamin D levels were measured using the ELISA technique, and genotyping of VDR polymorphisms was carried out using real-time polymerase chain reaction.

What Was Measured

In this case-control study, plasma vitamin D levels and VDR genotype frequencies of 70 cases (DFU patients) were compared with 70 diabetic (diabetes mellitus [DM] [non-DFU]) patients and 70 apparently healthy controls (HC) from South India.

PubMed files the paper under topics including Diabetic Foot, Receptors, Calcitriol, India, Vitamin D, Case-Control Studies, Polymorphism, Single Nucleotide and Tertiary Health Care.

The authors tagged it with the keywords VDR and diabetic foot ulcer.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2024 (International wound journal), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.