Evaluation of Aluminum and Magnesium Absorption Following the Oral Administration of an Antacid Suspension Containing Magaldrate in Healthy Women Under Fed Conditions.

Plain-language guide to PMID 39249590 (2024): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 39249590
Journal: Advances in therapy
Year: 2024
Study type: Randomized Controlled Trial
Authors: Burgos Castillo MJ et al. (6 authors)
DOI: 10.1007/s12325-024-02969-9
Registered trial: NCT06367452

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The aim of this study was to quantify the rate and magnitude of absorption of aluminum and magnesium in magaldrate.

Why It Was Studied

Antacids are commonly used during pregnancy, and they are approved for the relief of symptoms of gastroesophageal reflux disease (GERD) during pregnancy.

However, there are no reports of the quantification of the absorption of aluminum and magnesium in the antacid magaldrate in women.

Who Took Part

PubMed indexes the participants as young adults and adults, women only.

An open-label, controlled, randomized, one-treatment study with a two-group design was conducted in healthy women in a fed state.

How the Study Was Run

The design is described as randomized and open-label.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Everyone knew when Vitamin D, K2, Magnesium and Zinc was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Blood samples were obtained 36 h before and up to 12 h after antacid administration.

The method used for quantification was inductively coupled plasma-mass spectrometry.

What Was Measured

Topics PubMed links to this paper include Antacids, Magnesium, Aluminum, Aluminum Hydroxide, Magnesium Hydroxide, Sodium Bicarbonate and Drug Combinations.

Author keywords: Absorption, Magaldrate, Pregnancy and Women.

What This Means in Plain Language

The paper is a randomized and open-label study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2024 (Advances in therapy), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.