A double-blinded randomised control study to compare the effectiveness and safety of intralesional vitamin D3 with intralesional triamcinolone and its correlation with tissue expression of vitamin D receptors in patients with keloid.

Plain-language guide to PMID 39262166 (2024): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 39262166
Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Year: 2024
Study type: Randomized Controlled Trial
Authors: Goyal A et al. (10 authors)
DOI: 10.1111/wrr.13209

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Biopsies were taken pre- and post-treatment to examine VDR expression levels and treatment response correlation.

Why It Was Studied

Intralesional steroids commonly used for keloid treatment have adverse effects like cutaneous atrophy and telangiectasias.

Sixty patients were randomly assigned to two groups: Group A (intralesional vitamin D) and Group B (intralesional triamcinolone).

Who Took Part

By PubMed's age tags, the people studied were young adults, adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized and double-blind.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Four injections were given at 4-week intervals, with an 8-week follow-up.

What Was Measured

Secondary outcomes included incidence of adverse effects, and changes in VDR expression before and after treatment.

Baseline VSS scores were 9.73 ± 1.01 (vitamin D group) and 10.13 ± 1.07 (triamcinolone group).

Topics PubMed links to this paper include Receptors, Calcitriol, Keloid, Injections, Intralesional, Cholecalciferol, Triamcinolone, Glucocorticoids and Triamcinolone Acetonide.

Author keywords: therapy, vitamin D and vitamin D receptor.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2024 (Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.