Associations between vitamin D status and biomarkers linked with inflammation in patients with asthma: a systematic review and meta-analysis of interventional and observational studies.

Plain-language guide to PMID 39322954 (2024): meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 39322954
Journal: Respiratory research
Year: 2024
Study type: Meta-Analysis
Authors: El Abd A et al. (5 authors)
DOI: 10.1186/s12931-024-02967-z

What This Paper Covers, in Plain Language

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in this meta-analysis publication.

Numerous studies indicate an association between vitamin D status and inflammatory biomarkers in patients with asthma, but findings are inconsistent.

This review aims to summarize the relationship between serum vitamin D status, assessed by 25-hydroxyvitamin D (25(OH)D) level, and inflammatory biomarkers in children and adults with asthma.

How the Review Was Done

A literature search of interventional and observational studies on 25(OH)D up to November 2022 was conducted across six electronic databases.

Outcomes of interest included a range of inflammatory biomarkers classified in four categories: T helper 2 (Th2) pro-inflammatory, non-Th2 pro-inflammatory, anti-inflammatory, and non-specific biomarkers.

Study characteristics were extracted and risk of bias was evaluated using the American Academy of Nutrition and Dietetics tool.

Meta-analysis was conducted on studies with a low risk of bias, while narrative reporting was used to present the direction of associations (positive, no association, or negative) for each biomarker, overall and within the low-risk studies.

What Was Measured

This review aims to summarize the relationship between serum vitamin D status, assessed by 25-hydroxyvitamin D (25(OH)D) level, and inflammatory biomarkers in children and adults with asthma.

Topics PubMed links to this paper include Asthma, Biomarkers, Inflammation, Observational Studies as Topic, Vitamin D and Vitamin D Deficiency.

Author keywords: Meta-analysis and Systematic review.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2024 (Respiratory research), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.