Pancreatic Enzyme Replacement Leads to Increased Vitamin D Uptake in Patients Undergoing Sleeve-gastrectomy - A Prospective, Monocentric Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

A possible treatment option can be the implementation of pancreatic enzyme replacement (PERT) and may lead to better outcomes.

The researchers designed a prospective trial investigating the possible impact of PERT in patients undergoing MBS at a high-volume center.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

A prospective two-arm randomized controlled trial was conducted on patients who underwent either sleeve gastrectomy or gastric bypass procedures at a high-volume center.

Patients underwent bariatric surgery and follow-up examinations at 3, 6, and 12 months after surgery.

How the Study Was Run

The design is described as randomized.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Patients were stratified either to the treatment group with PERT or to the control group.

The primary endpoint of the study was a change in BMI.

Lab testing was carried out to measure secondary endpoints, including albumin and vitamin D levels.

What Was Measured

The subject headings attached to it are Obesity, Morbid, Gastrectomy, Vitamin D, Enzyme Replacement Therapy, Weight Loss, Quality of Life and Gastric Bypass.

Author keywords: Bariatric surgery, Clinical impact and Vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Obesity surgery), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.