Vitamin D in Multiple Sclerosis: A Comprehensive Umbrella Review.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of multiple sclerosis, published as a review.

The aim of this study was to evaluate the relationship of MS with 25(OH)D serum levels, VDR gene polymorphisms, and VDS.

Why It Was Studied

Multiple sclerosis (MS) is an inflammatory neuroimmune disease with a multifaceted etiology and long-lasting adverse effects.

Several studies have explored the role of 25-hydroxyvitamin D (25(OH)D) serum levels, vitamin D receptor (VDR) gene polymorphisms, and vitamin D supplementation (VDS) in individuals with MS.

Who the Included Studies Covered

The methodological quality of selected articles was assessed by the Assessment of Multiple Systematic Reviews version 2.

How the Review Was Done

The researchers assessed relevant articles published in PubMed, Scopus, and Web of Science from the inception up to 24 February, 2024.

Meta-analyses that investigated the link of 25(OH)D serum levels, VDR gene polymorphisms including Apal (rs7975232), BsmI (rs1544410), Taql (rs731236), and Fokl (rs10735810), and VDS with the risk and clinical manifestations of MS were included.

The statistical analysis of this umbrella review was carried out using RStudio version 2023.03.1 and R version 4.3.2, simultaneously.

What Was Measured

Several studies have explored the role of 25-hydroxyvitamin D (25(OH)D) serum levels, vitamin D receptor (VDR) gene polymorphisms, and vitamin D supplementation (VDS) in individuals with MS.

The subject headings attached to it are Multiple Sclerosis, Vitamin D, Receptors, Calcitriol, Polymorphism, Genetic and Dietary Supplements.

The authors tagged it with the keywords gene polymorphisms, serum level and supplementation.

What This Means in Plain Language

This is a review of Vitamin D, K2, Magnesium and Zinc in people with multiple sclerosis.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Multiple sclerosis research.