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Effect of fasting-induced headache on calcitonin gene related peptide (CGRP) and other clinical biomarkers on the first day of Ramadan: Sub-analysis from a randomized open label clinical trial
Plain-language guide to PMID 39415097 (2024): open-label randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide).
Key Facts
- PMID
- 39415097
- Journal
- The journal of headache and pain
- Year
- 2024
- Study type
- Randomized Controlled Trial
- Authors
- Alwhaibi A et al. (11 authors)
- DOI
- 10.1186/s10194-024-01886-0
What This Study Did, in Plain Language
What Was Tested
Researchers studied CGRP (Calcitonin Gene-Related Peptide) in this randomized controlled trial publication.
Their study aimed to investigate any association between FIHs during the first day of Ramadan and potential headache-related biomarkers, including fasting blood glucose (FBG), C-reactive protein (CRP), magnesium, vitamin B9, vitamin B12, homocysteine, and calcitonin gene related peptide (CGRP), and to assess whether a prophylactic use of paracetamol may influence these biomarkers.
Why It Was Studied
Despite the wealth of knowledge about different types of headaches (e.g., migraine-, cluster-, and tension-type headaches), research on the mechanism underlying FIHs, as well as their treatment, remains scarce.
This study was registered with the Saudi Food and Drug Authority in the Saudi Clinical Trials Registry (SCTR; No. 22122102).
Who Took Part
PubMed indexes the participants as young adults, adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized and open-label study.
Because people in this CGRP (Calcitonin Gene-Related Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Being open-label, the CGRP (Calcitonin Gene-Related Peptide) study did not mask who received what.
What Was Measured
The subject headings attached to it are Fasting, Calcitonin Gene-Related Peptide, Biomarkers, Islam, Headache, Acetaminophen and Analgesics, Non-Narcotic.
Author keywords: CGRP, Homocysteine and Ramadan.
What This Means in Plain Language
The paper is a randomized and open-label study of CGRP (Calcitonin Gene-Related Peptide).
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2024 (The journal of headache and pain), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, all human trials.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.