Effect of Time-Restricted Eating on Circulating Levels of IGF1 and Its Binding Proteins in Obesity: An Exploratory Analysis of a Randomized Controlled Trial.

What Was Tested

Researchers studied IGF-1 LR3 in this randomized controlled trial publication.

This study aimed to investigate the effects of TRE on plasma IGF1, IGFBP1, IGFBP2, and IGFBP3, and whether these effects were mediated by weight loss or body composition changes.

Insulin sensitivity, glucose control, adipokines, and inflammatory markers were also examined.

Why It Was Studied

However, the effects of 4 and 6 h time-restricted eating (TRE) on circulating IGF1 and IGFBPs is uncertain.

Repeated measures ANOVA and mediation analysis were conducted.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Participants with obesity were randomized to 4 or 6 h TRE (n = 35) or a control (n = 14) group.

Controls received no dietary recommendations.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the IGF-1 LR3 group and the comparison group should start out alike.

This study was conducted at the University of Illinois at Chicago in 2019.

Plasma biomarkers were measured by ELISA at baseline and week 8.

What Was Measured

Repeated measures ANOVA and mediation analysis were conducted.

PubMed files the paper under topics including Insulin-Like Growth Factor I, Obesity, Biomarkers, Weight Loss, Fasting, Insulin-Like Growth Factor Binding Proteins and Adipokines.

The authors tagged it with the keywords IGF1, IGFBP, growth hormones and intermittent fasting.

What This Means in Plain Language

The paper is a randomized study of IGF-1 LR3.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Nutrients), a journal based in Switzerland.

More context: the IGF-1 LR3 compound page, all human trials.