Vitamin D as a Modifiable Risk Factor for Juvenile Idiopathic Arthritis: A Systematic Review and Meta-analysis of Observational Studies Comparing Baseline Vitamin D in Children with JIA to Individuals Without.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc.

To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels, indicative of vitamin D, among patients diagnosed with JIA compared with control participants.

The aim was to elucidate potential therapeutic implications of vitamin D in the management of JIA.

Each article was reviewed by at least 2 independent reviewers to assess eligibility for analysis.

Why It Was Studied

The varying interactions contributing to the development of juvenile idiopathic arthritis (JIA) drive the struggle to understand its etiology.

Among the environmental risk factors, vitamin D has been posited to have a component in disease progression, acting as an inflammatory mediator.

Who the Included Studies Covered

By PubMed's age tags, the people studied were young children, children and teenagers, both men and women.

What Was Measured

Inclusion criteria required participants to be <16 years old (either clinically diagnosed with JIA or a matched control participant), with vitamin D levels measured through serum laboratory methods.

Exclusion criteria omitted studies in which participants used vitamin D supplementation or medications affecting vitamin D levels without corresponding statistical analyses on their association with vitamin D levels.

Topics PubMed links to this paper include Arthritis, Juvenile, Vitamin D, Risk Factors, Observational Studies as Topic, Vitamin D Deficiency and Dietary Supplements.

The authors tagged it with the keywords juvenile idiopathic arthritis (JIA), meta-analysis, pediatric and systematic review.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Nutrition reviews), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.