Effects of dexamethasone combined with vitamin B12 on percutaneous endoscopic interlaminar discectomy early outcomes: a randomized controlled trial

What Was Tested

Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.

Residual low back and leg pain can occur after percutaneous endoscopic interlaminar discectomy (PEID) and compromise early surgical outcomes.

This trial was registered with the China Clinical Trial Registration Center (Identifier: ChiCTR2400088854).

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

Patients who underwent PEID for lumbar disc herniation (LDH) were enrolled and randomly assigned to the single surgery (SS) group, where disc removal was performed via PEID alone, or the combined treatment (CT) group, which received epidural injections of dexamethasone and VB12 alongside surgery.

The outcome measures were the Visual Analog Scale (VAS), Japanese Orthopaedic Association (JOA) score, Oswestry Disability Index (ODI), serum inflammatory factor expression, adverse surgical events, duration of postoperative hospitalization, and modified MacNab criteria.

How the Study Was Run

In design terms this was a randomized study.

The participants were allocated by chance, so the Cyanocobalamin (Vitamin B12) group and the comparison group should start out alike.

What Was Measured

Residual low back and leg pain can occur after percutaneous endoscopic interlaminar discectomy (PEID) and compromise early surgical outcomes.

PubMed files the paper under topics including Vitamin B 12, Dexamethasone, Diskectomy, Percutaneous, Intervertebral Disc Displacement, Endoscopy, Lumbar Vertebrae and Low Back Pain.

Author keywords: Spinal endoscopy, lumbar disc herniation, postoperative pain and vitamin B12.

What This Means in Plain Language

The paper is a randomized study of Cyanocobalamin (Vitamin B12).

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Journal of orthopaedic surgery and research), a journal based in England.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.