← Human Trials & Peer-Reviewed Studies

Weight Loss Induces Changes in Vitamin D Status in Women With Obesity But Not in Men: A Randomized Clinical Trial.

Plain-language guide to PMID 39530599 (2025): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 195 individuals, fat loss, obesity & body recomposition.

Key Facts

PMID
39530599
Journal
The Journal of clinical endocrinology and metabolism
Year
2025
Study type
Randomized Controlled Trial
Authors
Holt R et al. (15 authors)
DOI
10.1210/clinem/dgae775
Registered trial
NCT04122716

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc in the context of fat loss, obesity & body recomposition.

The aim of this study was to investigate the effects of weight loss on vitamin D status in individuals with obesity, and secondarily, whether vitamin D metabolism differs between women and men.

Who Took Part

The abstract describes 195 individuals taking part.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a randomized and placebo-controlled study.

The individuals were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Some individuals received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

What Was Measured

The subject headings attached to it are Weight Loss, Obesity, Vitamin D, Caloric Restriction, Liraglutide, Sex Factors and Vitamin D Deficiency.

Author keywords: GLP-1 receptor agonist, glucagon-like peptide-1 and sex differences.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 195 individuals in people with fat loss, obesity & body recomposition.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Fat loss, obesity & body recomposition research.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.