Sex-specific association of per- and polyfluoroalkyl substances (PFAS) exposure with vitamin D concentrations in older adults in the USA: an observational study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

Moreover, they did not specifically focus on populations with longer duration of PFAS exposure and potentially higher blood PFAS levels, such as older adults, and lacked adequate evidence to examine sex-related disparities.

Survey-weighted multiple regression models were employed to evaluate the relationship between PFAS exposure and vitamin D concentrations.

Multi-pollutant models were employed to evaluate the association between PFAS mixtures and vitamin D concentrations.

Why It Was Studied

Per- and polyfluoroalkyl substances (PFAS) are commonly utilized in consumer products.

Who Took Part

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.

Subsequently, environmental risk scores (ERS) were constructed to gauge associations with vitamin D concentrations.

How the Study Was Run

This observational investigation utilized cross-sectional data obtained from the U.S.

NHANES spanning the years 2003 to 2018.

ERS was computed through a weighted linear combination of PFAS, utilizing calculations from ridge regression and adaptive elasticity network (adENET) methodologies.

All analyses were stratified by sex.

What Was Measured

The subject headings attached to it are Fluorocarbons, United States, Vitamin D, Environmental Pollutants, Cross-Sectional Studies, Environmental Exposure and Nutrition Surveys.

The authors tagged it with the keywords Co-exposure, ERS, Older adults and PFAS.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Environmental health : a global access science source), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.