The Effect of Vitamin D Supplementation on Quality of Life in Stage II-III Colorectal Cancer Patients Undergoing Adjuvant Chemotherapy: A Single-Blind, Randomized Controlled Trial.

Plain-language guide to PMID 39557774 (2024): single-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 39557774
Journal: Journal of gastrointestinal cancer
Year: 2024
Study type: Randomized Controlled Trial
Authors: Perinandika T et al. (3 authors)
DOI: 10.1007/s12029-024-01142-3

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Colorectal cancer is the third most common cancer with the second highest mortality worldwide in 2020.

Adjuvant chemotherapy is given for stage II-III colorectal cancer.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

A study regarding the effect of vitamin D supplementation on the quality of life of stage II-III colorectal cancer patients undergoing adjuvant chemotherapy from May 2022 to April 2023 at Hasan Sadikin Hospital was conducted.

A single-blinded, randomized controlled trial (RCT) with consecutive sampling was done at the digestive surgery outpatients.

How the Study Was Run

In design terms this was a randomized and single-blind study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

In this single-blind Vitamin D, K2, Magnesium and Zinc study one party knew the assignments and the other did not.

Data was taken from the medical record, history taking, and personal interviews.

Quality of life was measured at the first, third, and sixth months after chemotherapy using the validated Indonesian version of the EORTC QLQ-C30 questionnaire.

What Was Measured

PubMed files the paper under topics including Quality of Life, Colorectal Neoplasms, Vitamin D, Chemotherapy, Adjuvant, Neoplasm Staging, Dietary Supplements and Antineoplastic Combined Chemotherapy Protocols.

Author keywords: Adjuvant chemotherapy and Colorectal cancer.

What This Means in Plain Language

The paper is a randomized and single-blind study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (Journal of gastrointestinal cancer), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.