The effects of Omega-3 fatty acids and vitamin D supplementation on the quality of life and blood inflammation markers in newly diagnosed breast cancer women: An open-labelled randomised controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

There is limited evidence on the potential nutritional intervention to complement active oncological treatment strategies in breast cancer (BC) patients in developing countries.

The aim of the present study was to assess the effects of omega-3 fatty acids (ω3) and vitamin D3 (VitD) supplementations on the QoL and blood inflammation markers of tumor necrosis factor-alpha (TNF-α) and high-sensitive C-reactive protein (hsCRP) assessed among women newly diagnosed with BC in the Gaza Strip, Palestine.

Who Took Part

The abstract describes 88 women taking part.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, women only.

A total of 88 BC women were randomly assigned into one of four groups: i) omega-3 fatty acid (ω3) group; ii) vitamin D (VitD) group; iii) ω3+VitD group, and iv) the control.

The QoL status was assessed by the European Organization for Research and Treatment of Cancer (EORTC) instruments of QLQ-C30 and QLQ-BR23 tools, while blood inflammatory markers of TNF-α hsCRP were used.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

All measurements were taken from baseline to the end of the intervention period.

The detailed procedures of the present study were registered on ClinicalTrial.gov with the identifier NCT05331807.

What Was Measured

The subject headings attached to it are Fatty Acids, Omega-3, Breast Neoplasms, Quality of Life, Dietary Supplements, C-Reactive Protein, Biomarkers and Tumor Necrosis Factor-alpha.

Author keywords: 25-hydroxyvitamin D (25(OH)D), Blood inflammatory markers, Breast cancer and Omega-3 fatty acid.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 88 women.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.