Association of serum total folate and serum vitamin D concentrations with W-shape in depressed older adults with cognitive dysfunction: A cross-sectional observational study.

Plain-language guide to PMID 39581498 (2025): observational study of Vitamin D, K2, Magnesium and Zinc in 2014, participants.

Key Facts

PMID: 39581498
Journal: Clinical nutrition ESPEN
Year: 2025
Study type: Observational Study
Authors: Guo Q et al. (5 authors)
DOI: 10.1016/j.clnesp.2024.11.021

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.

The aim of this study was to elucidate the association between serum total folate and serum vitamin D concentrations and depressive symptoms and cognitive dysfunction in older adults.

Why It Was Studied

Depression and cognitive dysfunction are prevalent in the elderly population and have a serious impact on patients' quality of life and social functioning.

Who Took Part

The study group was 2014, participants.

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.

Using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014, 2042 participants aged 60 years and older were analyzed.

Depressive symptoms were assessed by the Patient Health Questionnaire (PHQ-9) and cognitive function was assessed by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Animal Fluency test and the Digit Symbol Substitution Test (DSST).

How the Study Was Run

Associations between serum total folate and vitamin D concentrations and depression with cognitive dysfunction were analyzed using multivariate logistic regression models, incorporating stratification and sensitivity analyses.

What Was Measured

The subject headings attached to it are Folic Acid, Cross-Sectional Studies, Vitamin D, Depression, Cognitive Dysfunction and Nutrition Surveys.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc in 2014, participants.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.