The Roles of Vitamin D Receptor (VDR) and CD8+ T-Lymphocytes in Acral and Mucosal Melanoma Invasion Depth.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this observational study publication.

This study aims to determine the association between the invasion depth of acral and mucosal melanomas with their VDR and CD8+ immunoexpression.

A chi-square test with an alternative Exact-Fisher analysis was used to determine the association between the variables in both subtype groups.

Why It Was Studied

Acral and mucosal melanomas, the most common sun-shielded site melanoma subtypes in Asia and Indonesia, often yield poor prognoses.

The invasion depth reflects their progressivity, and the pathogenesis is influenced by vitamin D receptor (VDR) status and CD8+ T-Lymphocyte amount.

Who Took Part

The age groups tagged for this paper are adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

A cross-sectional observational study was conducted on 60 formalin-fixed paraffin-embedded (FPPE) samples, with equal representation in acral and mucosal melanoma groups from 2017 to 2021.

The samples were assessed for the invasion depth and immunoexpression of VDR and CD8+.

What Was Measured

PubMed files the paper under topics including Receptors, Calcitriol, CD8-Positive T-Lymphocytes, Melanoma, Cross-Sectional Studies, Skin Neoplasms, Mucous Membrane and Neoplasm Invasiveness.

Author keywords: CD8+, VDR, acral melanoma, invasion depth and mucosal melanoma.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Journal of cutaneous pathology), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.