Association of Copper, Zinc, Copper-to-zinc ratio and Disease Severity Scores in Sickle Cell Anemia: An Observational Analytical Study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in the context of anemia in this observational study publication.

The purpose of the study was to assess the amount of serum copper, zinc, and copper-to-zinc ratio in sickle cell anemia patients and healthy subjects and to relate the parameters with an objective disease severity score.

Further, to see the correlation between copper and zinc levels with fetal hemoglobin level in sickle cell anemia (SCA) subjects in both stable state and during the crisis.

High-performance liquid chromatography (HPLC) was used to determine the fetal hemoglobin level of every participant.

Who Took Part

The abstract describes 100 subjects taking part.

By PubMed's age tags, the people studied were children, teenagers, young adults and adults, both men and women.

Copper and zinc levels in serum of 100 SCA and 100 healthy subjects were measured using commercially available kits.

The data were compared between SCA subjects in a stable state, crisis state, and control subjects using the Student's t-test, and the variables were linked with disease severity levels using the Pearson's correlation coefficient.

How the Study Was Run

The copper-to-zinc ratio was then obtained by dividing the copper and zinc levels.

What Was Measured

The subject headings attached to it are Anemia, Sickle Cell, Copper, Zinc, Case-Control Studies and Fetal Hemoglobin.

What This Means in Plain Language

This is an observational study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement) in 100 subjects in people with anemia.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2024 (The Journal of the Association of Physicians of India), a journal based in India.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, Anemia research.