Antimicrobial photodynamic therapy effects mediated by methylene blue in surfactant medium as an adjuvant treatment of teeth with apical periodontitis and presence of fistula-Protocol for randomized, controlled, double-blind clinical trial

What Was Tested

This clinical study looks at Methylene blue (non-peptide stack partner).

In this study, a fistula is characterized as a pathological conduit originating from the infected region at the root apex of the tooth, traversing the oral mucosa, and extending to the external surface of the gingiva.

This pathological condition frequently complicates the management of endodontic infections, thereby necessitating the evaluation of supplementary therapeutic interventions.

The standard treatment for endodontic infections involves thorough disinfection of the root canal system to remove microbial contamination from the canal and surrounding tissues.

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

The teeth will be randomly assigned to one of two treatment groups.

Group I will receive only the conventional endodontic treatment, which includes root canal cleaning, shaping, and obturation.

How the Study Was Run

The design is described as randomized and double-blind.

Because people in this Methylene blue (non-peptide stack partner) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Methylene blue (non-peptide stack partner) study, the assignments were hidden from both participants and investigators until the end.

The study will involve 140 teeth with apical periodontitis and fistulas.

Group II will undergo the same conventional endodontic treatment, but with an additional step of aPDT.

The aPDT procedure involves applying a photosensitizer to the root canal and irradiating it with light to produce reactive oxygen species.

Each group will consist of 70 teeth to ensure adequate statistical power.

The primary outcome is fistula resolution, assessed clinically at 15 and 30 days post-treatment.

What Was Measured

Topics PubMed links to this paper include Periapical Periodontitis, Photochemotherapy, Methylene Blue, Surface-Active Agents, Photosensitizing Agents, Root Canal Therapy and Randomized Controlled Trials as Topic.

What This Means in Plain Language

The paper is a randomized and double-blind study of Methylene blue (non-peptide stack partner).

Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2024 (PloS one), a journal based in United States.

More context: the Methylene blue (non-peptide stack partner) compound page, all human trials.