The Effects of a Food Supplement, Based on Co-Micronized Palmitoylethanolamide (PEA)-Rutin and Hydroxytyrosol, in Metabolic Syndrome Patients: Preliminary Results.

What Was Tested

This randomized controlled trial looks at Copper (Supplement).

The aim of their randomized crossover double-blind placebo-controlled pilot study was to evaluate the potential effects of a food supplement (FS) containing a co-micronized formulation of PEA and rutin along with HTyr, combined with a tailored calorie-controlled Mediterranean diet, in patients with MetS.

Why It Was Studied

Metabolic syndrome (MetS) patients have impaired hypothalamic regulatory functions involved in food intake and energy expenditure and suffer from a state of meta-inflammation.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Nineteen patients were enrolled and block-randomized to an eight-week MD together with the FS or placebo.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled, crossover and pilot study.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Copper (Supplement).

Some participants received a placebo instead of Copper (Supplement), giving a reference point.

In the crossover set-up each of the participants took both Copper (Supplement) and the comparison in turn, acting as their own control.

Data on laboratory parameters and those detected by capillary sampling, anthropometry, body composition analysis, ultrasound examination, blood pressure monitoring, the 36-Item Short-Form Health Survey questionnaire, handgrip strength test, and physical performance tests were collected at each time point (protocol code R.S. 262.22, registered on 20 December 2022).

What Was Measured

PubMed files the paper under topics including Palmitic Acids, Metabolic Syndrome, Dietary Supplements, Amides, Phenylethyl Alcohol, Pilot Projects and Ethanolamines.

The authors tagged it with the keywords adiposopathy, body composition assessment, co-micronized palmitoylethanolamide, hydroxytyrosol, mediterranean diet and meta-inflammation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (Nutrients), a journal based in Switzerland.

More context: the Copper (Supplement) compound page, all human trials.